Heat stability of the lyophilized Sabin poliovaccine.
نویسندگان
چکیده
In this study we lyophilized three types of live attenuated polioviruses (Sabin vaccine strains) and evaluated the lyophilized vaccine viruses' heat stability. The virus titers were measured after heating at 37 and 45 and then compared with the titers of conventional liquid vaccine viruses similarly treated. The results showed that lyophilization, while slightly reducing vaccine virus titers, had a far greater sparing effect on subsequent heat inactivation of lyophilized vaccine viruses, thus demonstrating its validity for the improvement of the vaccine.
منابع مشابه
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ورودعنوان ژورنال:
- Japanese journal of infectious diseases
دوره 56 2 شماره
صفحات -
تاریخ انتشار 2003